STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tb11.02.0530Phosphoribosylpyrophosphate synthetase, putative. (441 aa)    
Predicted Functional Partners:
Tb927.8.6170
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 
 0.943
Tb927.5.3170
Ribose-phosphate pyrophosphokinase, putative.
  
0.942
Tb11.03.0090
Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
  
 0.931
Tb11.01.0700
Ribose 5-phosphate isomerase, putative.
    
 0.924
Tb927.5.3810
Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative.
  
 
 0.922
Tb11.01.1570
NUDIX hydrolase, conserved; Belongs to the Nudix hydrolase family.
  
 
 0.908
Tb927.5.2960
Phosphoribosylpyrophosphate synthetase, putative.
  
  
 
0.810
Tb10.6k15.0970
Phosphoribosylpyrophosphate synthetase, putative.
  
  
 
0.807
Tb927.3.2840
Inorganic pyrophosphatase, putative.
  
  
 0.796
Tb11.02.4910
Acidocalcisomal pyrophosphatase.
  
  
 0.748
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
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