STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tb927.8.4430Nucleoside phosphorylase, putative. (341 aa)    
Predicted Functional Partners:
Tb09.160.1680
Cytidine deaminase, putative.
  
  
 0.868
Tb927.2.2460
Ubiquitin-conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.
    
   0.781
Tb927.7.7040
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
     
 0.720
Tb927.7.5680
Deoxyribose-phosphate aldolase, putative.
  
  
 0.692
Tb927.7.1930
Nucleoside diphosphatase, putative; Belongs to the GDA1/CD39 NTPase family.
      
 0.690
Tb11.18.0006
Carnitine O-acetyltransferase, putative.
      
 0.688
Tb927.7.5480
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.
  
  
 0.561
Tb927.5.3830
Dihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
     
 0.531
Tb927.4.3320
Uracil phosphoribosyltransferase, putative.
   
 
 0.528
Tb927.5.3810
Orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative.
     
 0.525
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
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