STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tb927.8.3500MMS19_N domain-containing protein. (947 aa)    
Predicted Functional Partners:
Tb927.8.3860
Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
    
 0.990
Tb927.8.720
FeS_assembly_P domain-containing protein.
    
 0.982
Tb09.211.1780
Uncharacterized protein.
    
 0.928
Tb927.8.5980
TFIIH basal transcription factor complex helicase subunit, putative.
    
 0.816
Tb927.2.1800
DNA polymerase.
    
 0.667
Tb927.6.3510
tRNA modification enzyme, putative.
   
 
 0.659
XPB
TFIIH basal transcription factor complex helicase XPB subunit; ATP-dependent 3'-5' DNA helicase, component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II. TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP- dependent helicase activity of XPB is required for promoter opening and promoter escape (By similarity).
   
 
 0.647
Tb10.406.0260
Iron-containing hydrogenase, putative; Belongs to the NARF family.
    
 0.624
Tb09.211.1820
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
    
 0.547
Tb927.8.3920
MMS19_N domain-containing protein.
     
0.544
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.