STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tb927.4.1350Hydroxyacylglutathione hydrolase, putative. (464 aa)    
Predicted Functional Partners:
Tb927.6.1080
Hydroxyacylglutathione hydrolase, putative.
  
  
 
0.915
Tb927.4.1340
Cleavage and polyadenylation specificity factor subunit, putative.
  
  
 0.796
Tb927.2.5180
Aldo-keto reductase, putative.
  
  
 0.785
Tb927.5.3210
Small ubiquitin protein, putative.
      
 0.688
Tb927.6.4400
Uncharacterized protein.
      
 0.683
Tb927.6.4450
Uncharacterized protein.
      
 0.683
Tb10.70.4980
Pyr_redox_2 domain-containing protein.
   
 0.646
Tb927.7.5480
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.
     
 0.509
Tb927.4.1330
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
      
 0.465
Tb927.6.2040
Nitrate reductase, putative.
  
  
 0.407
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
Server load: low (18%) [HD]