node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFR88300.1 | SFS07407.1 | SAMN05216570_0273 | SAMN05216570_2264 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.818 |
SFR88300.1 | glyA | SAMN05216570_0273 | SAMN05216570_2218 | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.482 |
SFS07407.1 | SFR88300.1 | SAMN05216570_2264 | SAMN05216570_0273 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. | 0.818 |
SFS07407.1 | SFS07985.1 | SAMN05216570_2264 | SAMN05216570_2339 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Cystathionine beta-synthase. | 0.749 |
SFS07407.1 | SFS08242.1 | SAMN05216570_2264 | SAMN05216570_2375 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase. | 0.704 |
SFS07407.1 | SFS16364.1 | SAMN05216570_2264 | SAMN05216570_3293 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase. | 0.697 |
SFS07407.1 | SFS16503.1 | SAMN05216570_2264 | SAMN05216570_3322 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Acetolactate synthase, small subunit. | 0.709 |
SFS07407.1 | SFS16563.1 | SAMN05216570_2264 | SAMN05216570_3334 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine dehydrogenase. | 0.753 |
SFS07407.1 | glyA | SAMN05216570_2264 | SAMN05216570_2218 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.875 |
SFS07407.1 | ilvA | SAMN05216570_2264 | SAMN05216570_3321 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.697 |
SFS07407.1 | serC | SAMN05216570_2264 | SAMN05216570_3153 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.780 |
SFS07407.1 | thrB | SAMN05216570_2264 | SAMN05216570_3333 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.704 |
SFS07985.1 | SFS07407.1 | SAMN05216570_2339 | SAMN05216570_2264 | Cystathionine beta-synthase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.749 |
SFS07985.1 | SFS08242.1 | SAMN05216570_2339 | SAMN05216570_2375 | Cystathionine beta-synthase. | UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase. | 0.963 |
SFS07985.1 | SFS16364.1 | SAMN05216570_2339 | SAMN05216570_3293 | Cystathionine beta-synthase. | Threonine dehydratase. | 0.785 |
SFS07985.1 | SFS16503.1 | SAMN05216570_2339 | SAMN05216570_3322 | Cystathionine beta-synthase. | Acetolactate synthase, small subunit. | 0.728 |
SFS07985.1 | SFS16563.1 | SAMN05216570_2339 | SAMN05216570_3334 | Cystathionine beta-synthase. | Homoserine dehydrogenase. | 0.841 |
SFS07985.1 | glyA | SAMN05216570_2339 | SAMN05216570_2218 | Cystathionine beta-synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.845 |
SFS07985.1 | ilvA | SAMN05216570_2339 | SAMN05216570_3321 | Cystathionine beta-synthase. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.785 |
SFS07985.1 | serC | SAMN05216570_2339 | SAMN05216570_3153 | Cystathionine beta-synthase. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.754 |