node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDC05264.1 | SDC38608.1 | SAMN05216345_101344 | SAMN05216345_10274 | Homoserine dehydrogenase. | Methionine biosynthesis protein MetW. | 0.606 |
SDC05264.1 | SDC70691.1 | SAMN05216345_101344 | SAMN05216345_103362 | Homoserine dehydrogenase. | Cystathionine beta-lyase. | 0.923 |
SDC05264.1 | SDD03402.1 | SAMN05216345_101344 | SAMN05216345_105301 | Homoserine dehydrogenase. | Phosphoserine phosphatase. | 0.701 |
SDC05264.1 | SDD06585.1 | SAMN05216345_101344 | SAMN05216345_105440 | Homoserine dehydrogenase. | O-acetylhomoserine sulfhydrylase. | 0.964 |
SDC05264.1 | glyA | SAMN05216345_101344 | SAMN05216345_101908 | Homoserine dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.674 |
SDC05264.1 | ilvA | SAMN05216345_101344 | SAMN05216345_102279 | Homoserine dehydrogenase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.712 |
SDC05264.1 | metXS | SAMN05216345_101344 | SAMN05216345_10273 | Homoserine dehydrogenase. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.905 |
SDC05264.1 | metZ | SAMN05216345_101344 | SAMN05216345_101664 | Homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.963 |
SDC05264.1 | thrB | SAMN05216345_101344 | SAMN05216345_101812 | Homoserine dehydrogenase. | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. | 0.959 |
SDC05264.1 | trpB | SAMN05216345_101344 | SAMN05216345_101672 | Homoserine dehydrogenase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.572 |
SDC38608.1 | SDC05264.1 | SAMN05216345_10274 | SAMN05216345_101344 | Methionine biosynthesis protein MetW. | Homoserine dehydrogenase. | 0.606 |
SDC38608.1 | SDC70691.1 | SAMN05216345_10274 | SAMN05216345_103362 | Methionine biosynthesis protein MetW. | Cystathionine beta-lyase. | 0.425 |
SDC38608.1 | SDD06585.1 | SAMN05216345_10274 | SAMN05216345_105440 | Methionine biosynthesis protein MetW. | O-acetylhomoserine sulfhydrylase. | 0.725 |
SDC38608.1 | metXS | SAMN05216345_10274 | SAMN05216345_10273 | Methionine biosynthesis protein MetW. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.998 |
SDC38608.1 | metZ | SAMN05216345_10274 | SAMN05216345_101664 | Methionine biosynthesis protein MetW. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.478 |
SDC38608.1 | thrB | SAMN05216345_10274 | SAMN05216345_101812 | Methionine biosynthesis protein MetW. | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. | 0.657 |
SDC70691.1 | SDC05264.1 | SAMN05216345_103362 | SAMN05216345_101344 | Cystathionine beta-lyase. | Homoserine dehydrogenase. | 0.923 |
SDC70691.1 | SDC38608.1 | SAMN05216345_103362 | SAMN05216345_10274 | Cystathionine beta-lyase. | Methionine biosynthesis protein MetW. | 0.425 |
SDC70691.1 | SDD03402.1 | SAMN05216345_103362 | SAMN05216345_105301 | Cystathionine beta-lyase. | Phosphoserine phosphatase. | 0.478 |
SDC70691.1 | SDD06585.1 | SAMN05216345_103362 | SAMN05216345_105440 | Cystathionine beta-lyase. | O-acetylhomoserine sulfhydrylase. | 0.963 |