node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEC45501.1 | SEC46246.1 | SAMN05216483_1738 | SAMN05216483_1752 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.973 |
SEC45501.1 | SEC46305.1 | SAMN05216483_1738 | SAMN05216483_1753 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, large subunit. | 0.948 |
SEC45501.1 | SEC87049.1 | SAMN05216483_1738 | SAMN05216483_2576 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. | 0.935 |
SEC45501.1 | ilvC | SAMN05216483_1738 | SAMN05216483_1751 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.915 |
SEC45501.1 | ilvD | SAMN05216483_1738 | SAMN05216483_3595 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.970 |
SEC45501.1 | leuA | SAMN05216483_1738 | SAMN05216483_4180 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.898 |
SEC45501.1 | leuA-2 | SAMN05216483_1738 | SAMN05216483_4396 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.898 |
SEC45501.1 | leuB | SAMN05216483_1738 | SAMN05216483_1740 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.975 |
SEC46246.1 | SEC45501.1 | SAMN05216483_1752 | SAMN05216483_1738 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.973 |
SEC46246.1 | SEC46305.1 | SAMN05216483_1752 | SAMN05216483_1753 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SEC46246.1 | SEC72782.1 | SAMN05216483_1752 | SAMN05216483_2280 | Acetolactate synthase, small subunit. | Threonine dehydratase. | 0.977 |
SEC46246.1 | SEC87049.1 | SAMN05216483_1752 | SAMN05216483_2576 | Acetolactate synthase, small subunit. | 2-oxoglutarate ferredoxin oxidoreductase subunit alpha. | 0.930 |
SEC46246.1 | SED76464.1 | SAMN05216483_1752 | SAMN05216483_4502 | Acetolactate synthase, small subunit. | Threonine dehydratase. | 0.977 |
SEC46246.1 | ilvC | SAMN05216483_1752 | SAMN05216483_1751 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SEC46246.1 | ilvD | SAMN05216483_1752 | SAMN05216483_3595 | Acetolactate synthase, small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.935 |
SEC46246.1 | leuA | SAMN05216483_1752 | SAMN05216483_4180 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.980 |
SEC46246.1 | leuA-2 | SAMN05216483_1752 | SAMN05216483_4396 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.980 |
SEC46246.1 | leuB | SAMN05216483_1752 | SAMN05216483_1740 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.997 |
SEC46305.1 | SEC45501.1 | SAMN05216483_1753 | SAMN05216483_1738 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.948 |
SEC46305.1 | SEC46246.1 | SAMN05216483_1753 | SAMN05216483_1752 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |