node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEC47121.1 | SEC47177.1 | SAMN05216483_1769 | SAMN05216483_1770 | Cobalamin-independent synthase, Catalytic domain. | Short-chain dehydrogenase. | 0.871 |
SEC47121.1 | SED86001.1 | SAMN05216483_1769 | SAMN05216483_4722 | Cobalamin-independent synthase, Catalytic domain. | Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor. | 0.869 |
SEC47121.1 | SED87459.1 | SAMN05216483_1769 | SAMN05216483_4762 | Cobalamin-independent synthase, Catalytic domain. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.992 |
SEC47121.1 | SEE04440.1 | SAMN05216483_1769 | SAMN05216483_5203 | Cobalamin-independent synthase, Catalytic domain. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.982 |
SEC47121.1 | ahcY | SAMN05216483_1769 | SAMN05216483_3963 | Cobalamin-independent synthase, Catalytic domain. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.969 |
SEC47121.1 | folD | SAMN05216483_1769 | SAMN05216483_2391 | Cobalamin-independent synthase, Catalytic domain. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.890 |
SEC47121.1 | gcvH | SAMN05216483_1769 | SAMN05216483_1791 | Cobalamin-independent synthase, Catalytic domain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.859 |
SEC47121.1 | gcvP | SAMN05216483_1769 | SAMN05216483_5479 | Cobalamin-independent synthase, Catalytic domain. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.907 |
SEC47121.1 | gcvT | SAMN05216483_1769 | SAMN05216483_1790 | Cobalamin-independent synthase, Catalytic domain. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.862 |
SEC47121.1 | metK | SAMN05216483_1769 | SAMN05216483_5402 | Cobalamin-independent synthase, Catalytic domain. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.982 |
SEC47177.1 | SEC47121.1 | SAMN05216483_1770 | SAMN05216483_1769 | Short-chain dehydrogenase. | Cobalamin-independent synthase, Catalytic domain. | 0.871 |
SED86001.1 | SEC47121.1 | SAMN05216483_4722 | SAMN05216483_1769 | Menaquinol-cytochrome c reductase cytochrome c1 subunit precursor. | Cobalamin-independent synthase, Catalytic domain. | 0.869 |
SED87459.1 | SEC47121.1 | SAMN05216483_4762 | SAMN05216483_1769 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Cobalamin-independent synthase, Catalytic domain. | 0.992 |
SED87459.1 | SEE04440.1 | SAMN05216483_4762 | SAMN05216483_5203 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SED87459.1 | ahcY | SAMN05216483_4762 | SAMN05216483_3963 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.708 |
SED87459.1 | folD | SAMN05216483_4762 | SAMN05216483_2391 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.945 |
SED87459.1 | gcvH | SAMN05216483_4762 | SAMN05216483_1791 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.903 |
SED87459.1 | gcvP | SAMN05216483_4762 | SAMN05216483_5479 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.947 |
SED87459.1 | gcvT | SAMN05216483_4762 | SAMN05216483_1790 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
SED87459.1 | metK | SAMN05216483_4762 | SAMN05216483_5402 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.963 |