node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEC41583.1 | SED40907.1 | SAMN05216483_1658 | SAMN05216483_3779 | Molecular chaperone HtpG. | Protein of unknown function. | 0.998 |
SEC41583.1 | dnaJ-2 | SAMN05216483_1658 | SAMN05216483_4378 | Molecular chaperone HtpG. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.996 |
SEC41583.1 | dnaK | SAMN05216483_1658 | SAMN05216483_3357 | Molecular chaperone HtpG. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
SEC41583.1 | groL | SAMN05216483_1658 | SAMN05216483_2446 | Molecular chaperone HtpG. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.979 |
SEC41583.1 | groL-2 | SAMN05216483_1658 | SAMN05216483_2822 | Molecular chaperone HtpG. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.979 |
SEC41583.1 | grpE | SAMN05216483_1658 | SAMN05216483_3358 | Molecular chaperone HtpG. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.893 |
SED07566.1 | SEE30032.1 | SAMN05216483_3064 | SAMN05216483_5857 | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II. | Amino acid adenylation domain-containing protein. | 0.999 |
SED07566.1 | dnaJ-2 | SAMN05216483_3064 | SAMN05216483_4378 | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.943 |
SED18298.1 | SED40907.1 | SAMN05216483_3301 | SAMN05216483_3779 | Protein phosphatase. | Protein of unknown function. | 0.564 |
SED18298.1 | SEE30032.1 | SAMN05216483_3301 | SAMN05216483_5857 | Protein phosphatase. | Amino acid adenylation domain-containing protein. | 0.423 |
SED18298.1 | dnaJ-2 | SAMN05216483_3301 | SAMN05216483_4378 | Protein phosphatase. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.950 |
SED18298.1 | dnaK | SAMN05216483_3301 | SAMN05216483_3357 | Protein phosphatase. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.564 |
SED40907.1 | SEC41583.1 | SAMN05216483_3779 | SAMN05216483_1658 | Protein of unknown function. | Molecular chaperone HtpG. | 0.998 |
SED40907.1 | SED18298.1 | SAMN05216483_3779 | SAMN05216483_3301 | Protein of unknown function. | Protein phosphatase. | 0.564 |
SED40907.1 | SEE30032.1 | SAMN05216483_3779 | SAMN05216483_5857 | Protein of unknown function. | Amino acid adenylation domain-containing protein. | 0.520 |
SED40907.1 | dnaJ-2 | SAMN05216483_3779 | SAMN05216483_4378 | Protein of unknown function. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.996 |
SED40907.1 | groL | SAMN05216483_3779 | SAMN05216483_2446 | Protein of unknown function. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.964 |
SED40907.1 | groL-2 | SAMN05216483_3779 | SAMN05216483_2822 | Protein of unknown function. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.964 |
SED40907.1 | grpE | SAMN05216483_3779 | SAMN05216483_3358 | Protein of unknown function. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.997 |
SED40907.1 | hrcA | SAMN05216483_3779 | SAMN05216483_4377 | Protein of unknown function. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.908 |