yhjX protein (Luteitalea pratensis) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Score

yhjX

Putative MFS-type transporter YhjX. (423 aa)

Predicted Functional Partners:

liaS_1

0.780

degU_1

0.777

thcD

0.550

ttgI_1

0.549

acrA

0.546

bepE_1

0.546

cysG_4

0.479

fabG_3

0.437

Your Current Organism:

Luteitalea pratensis

NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
acrA	bepE_1	LuPra_00450	LuPra_00451	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	0.961
acrA	degU_1	LuPra_00450	LuPra_00448	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Protease production enhancer protein.	0.546
acrA	liaS_1	LuPra_00450	LuPra_00449	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Sensor histidine kinase LiaS.	0.546
acrA	ttgI_1	LuPra_00450	LuPra_00452	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Toluene efflux pump outer membrane protein TtgI.	0.955
acrA	yhjX	LuPra_00450	LuPra_00447	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Putative MFS-type transporter YhjX.	0.546
bepE_1	acrA	LuPra_00451	LuPra_00450	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.961
bepE_1	degU_1	LuPra_00451	LuPra_00448	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Protease production enhancer protein.	0.548
bepE_1	liaS_1	LuPra_00451	LuPra_00449	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Sensor histidine kinase LiaS.	0.546
bepE_1	ttgI_1	LuPra_00451	LuPra_00452	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Toluene efflux pump outer membrane protein TtgI.	0.969
bepE_1	yhjX	LuPra_00451	LuPra_00447	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	Putative MFS-type transporter YhjX.	0.546
cysG_4	thcD	LuPra_05951	LuPra_01163	Uroporphyrinogen-III C-methyltransferase.	Rhodocoxin reductase.	0.905
cysG_4	yhjX	LuPra_05951	LuPra_00447	Uroporphyrinogen-III C-methyltransferase.	Putative MFS-type transporter YhjX.	0.479
degU_1	acrA	LuPra_00448	LuPra_00450	Protease production enhancer protein.	Acriflavine resistance protein A; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.546
degU_1	bepE_1	LuPra_00448	LuPra_00451	Protease production enhancer protein.	Efflux pump membrane transporter BepE; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	0.548
degU_1	fabG_3	LuPra_00448	LuPra_00446	Protease production enhancer protein.	3-oxoacyl-[acyl-carrier-protein] reductase FabG.	0.437
degU_1	liaS_1	LuPra_00448	LuPra_00449	Protease production enhancer protein.	Sensor histidine kinase LiaS.	0.962
degU_1	ttgI_1	LuPra_00448	LuPra_00452	Protease production enhancer protein.	Toluene efflux pump outer membrane protein TtgI.	0.546
degU_1	yhjX	LuPra_00448	LuPra_00447	Protease production enhancer protein.	Putative MFS-type transporter YhjX.	0.777
fabG_3	degU_1	LuPra_00446	LuPra_00448	3-oxoacyl-[acyl-carrier-protein] reductase FabG.	Protease production enhancer protein.	0.437
fabG_3	liaS_1	LuPra_00446	LuPra_00449	3-oxoacyl-[acyl-carrier-protein] reductase FabG.	Sensor histidine kinase LiaS.	0.437

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.841

expected number of edges:

13

PPI enrichment p-value:

0.00128

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006172

ADP biosynthetic process

2 of 2

3.04

1.56

0.0015

GO:0009179

Purine ribonucleoside diphosphate metabolic process

3 of 19

2.24

1.51

0.0014

GO:0009167

Purine ribonucleoside monophosphate metabolic process

3 of 20

2.22

1.51

0.0014

GO:0032386

Regulation of intracellular transport

3 of 25

2.12

1.49

0.0014

GO:0003400

Regulation of COPII vesicle coating

2 of 4

2.74

1.44

0.0024

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050145

Nucleoside monophosphate kinase activity

3 of 6

2.74

2.27

6.86e-05

GO:0004017

Adenylate kinase activity

2 of 3

2.87

1.41

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6770

Multivesicular body sorting pathway, and Calpain-like thiol protease family.

6 of 31

2.33

4.58

4.21e-10

CL:6820

Calpain-like thiol protease family., and Regulation of COPII vesicle coating

4 of 6

2.87

3.97

4.53e-08

CL:12808

Metabolism of nucleotides, and Biosynthesis of maresins

3 of 56

1.77

1.05

0.0078

CL:6793

Multivesicular body sorting pathway

2 of 10

2.35

0.95

0.0176

CL:12890

Deoxyribonucleotide biosynthetic process, and Nucleoside monophosphate kinase activity

2 of 15

2.17

0.87

0.0245

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04626

Plant-pathogen interaction

2 of 5

2.65

1.62

0.0011

map00230

Purine metabolism

4 of 100

1.65

1.6

0.00023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 25

2.12

1.46

0.0016

MAP-15869

Metabolism of nucleotides

3 of 68

1.69

0.92

0.0140

MAP-9668328

Sealing of the nuclear envelope (NE) by ESCRT-III

2 of 13

2.23

0.88

0.0239

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042584

Chromaffin granule membrane

2 of 3

2.87

1.19

0.0071

GOCC:0005935

Cellular bud neck

2 of 18

2.09

0.85

0.0258

GOCC:0043227

Membrane-bounded organelle

9 of 3197

0.49

0.33

0.0258

GOCC:0043229

Intracellular organelle

10 of 4076

0.43

0.3

0.0258

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

2 of 2

3.04

1.31

0.0044

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036193

Adenylate kinase, active site lid domain superfamily

2 of 2

3.04

1.06

0.0125

IPR007862

Adenylate kinase, active site lid domain

2 of 2

3.04

1.06

0.0125

IPR006259

Adenylate kinase subfamily

2 of 2

3.04

1.06

0.0125

IPR033690

Adenylate kinase, conserved site

2 of 3

2.87

1.05

0.0125

IPR000850

Adenylate kinase/UMP-CMP kinase

2 of 3

2.87

1.05

0.0125

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00054

EF-hand, calcium binding motif

2 of 15

2.17

0.81

0.0317

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