LuPra_05294 protein (Luteitalea pratensis) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

LuPra_05294

DUF1080 domain-containing protein. (253 aa)

Predicted Functional Partners:

LuPra_04536

0.976

LuPra_05295

0.808

LuPra_00304

0.774

iolG_1

0.774

gfo_4

0.774

LuPra_05697

0.773

LuPra_03226

0.771

LuPra_05223

0.770

LuPra_02306

0.769

afr_1

0.768

Your Current Organism:

Luteitalea pratensis

NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LuPra_00304	LuPra_02306	LuPra_00304	LuPra_02306	Glycosyl hydrolase family 109 protein 1.	DUF1080 domain-containing protein.	0.746
LuPra_00304	LuPra_03226	LuPra_00304	LuPra_03226	Glycosyl hydrolase family 109 protein 1.	DUF1080 domain-containing protein.	0.696
LuPra_00304	LuPra_04536	LuPra_00304	LuPra_04536	Glycosyl hydrolase family 109 protein 1.	DUF1080 domain-containing protein.	0.709
LuPra_00304	LuPra_05223	LuPra_00304	LuPra_05223	Glycosyl hydrolase family 109 protein 1.	DUF1080 domain-containing protein.	0.706
LuPra_00304	LuPra_05294	LuPra_00304	LuPra_05294	Glycosyl hydrolase family 109 protein 1.	DUF1080 domain-containing protein.	0.774
LuPra_02306	LuPra_00304	LuPra_02306	LuPra_00304	DUF1080 domain-containing protein.	Glycosyl hydrolase family 109 protein 1.	0.746
LuPra_02306	LuPra_03226	LuPra_02306	LuPra_03226	DUF1080 domain-containing protein.	DUF1080 domain-containing protein.	0.718
LuPra_02306	LuPra_04536	LuPra_02306	LuPra_04536	DUF1080 domain-containing protein.	DUF1080 domain-containing protein.	0.759
LuPra_02306	LuPra_05223	LuPra_02306	LuPra_05223	DUF1080 domain-containing protein.	DUF1080 domain-containing protein.	0.751
LuPra_02306	LuPra_05294	LuPra_02306	LuPra_05294	DUF1080 domain-containing protein.	DUF1080 domain-containing protein.	0.769
LuPra_02306	LuPra_05697	LuPra_02306	LuPra_05697	DUF1080 domain-containing protein.	Oxidoreductase family, NAD-binding Rossmann fold.	0.770
LuPra_02306	afr_1	LuPra_02306	LuPra_01789	DUF1080 domain-containing protein.	1,5-anhydro-D-fructose reductase.	0.764
LuPra_02306	gfo_4	LuPra_02306	LuPra_02139	DUF1080 domain-containing protein.	Glucose--fructose oxidoreductase.	0.760
LuPra_02306	iolG_1	LuPra_02306	LuPra_00935	DUF1080 domain-containing protein.	Inositol 2-dehydrogenase.	0.753
LuPra_03226	LuPra_00304	LuPra_03226	LuPra_00304	DUF1080 domain-containing protein.	Glycosyl hydrolase family 109 protein 1.	0.696
LuPra_03226	LuPra_02306	LuPra_03226	LuPra_02306	DUF1080 domain-containing protein.	DUF1080 domain-containing protein.	0.718
LuPra_03226	LuPra_05294	LuPra_03226	LuPra_05294	DUF1080 domain-containing protein.	DUF1080 domain-containing protein.	0.771
LuPra_03226	LuPra_05697	LuPra_03226	LuPra_05697	DUF1080 domain-containing protein.	Oxidoreductase family, NAD-binding Rossmann fold.	0.738
LuPra_03226	afr_1	LuPra_03226	LuPra_01789	DUF1080 domain-containing protein.	1,5-anhydro-D-fructose reductase.	0.641
LuPra_03226	gfo_4	LuPra_03226	LuPra_02139	DUF1080 domain-containing protein.	Glucose--fructose oxidoreductase.	0.722

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.823

expected number of edges:

11

PPI enrichment p-value:

1.3e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

8 of 26

2.04

4.96

8.45e-13

GO:0000160

Phosphorelay signal transduction system

9 of 47

1.84

4.28

7.99e-13

GO:0050794

Regulation of cellular process

10 of 372

0.98

1.17

6.21e-08

GO:0006355

Regulation of transcription, DNA-templated

5 of 266

0.83

0.5

0.0265

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

9 of 27

2.08

5.72

5.75e-15

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 22

1.69

1.35

0.0013

GO:0016021

Integral component of membrane

10 of 941

0.58

0.48

0.00059

GO:0005886

Plasma membrane

8 of 948

0.48

0.34

0.0169

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4951

Phosphorelay signal transduction system, and Nucleotide cyclase

11 of 55

1.86

5.34

1.03e-17

CL:4953

Phosphorelay signal transduction system, and Nucleotide cyclase

9 of 35

1.97

5.11

2.62e-14

CL:4955

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and OmpR/PhoB-type DNA-binding domain

6 of 16

2.13

4.18

7.10e-10

CL:4957

Two-component regulatory system, and Histidine kinase N terminal

5 of 11

2.21

3.69

2.44e-08

CL:4969

Two-component regulatory system

3 of 5

2.33

2.15

7.94e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

far02020

Two-component system

8 of 90

1.5

2.57

1.76e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

10 of 700

0.71

0.63

8.76e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 106

1.48

2.68

1.23e-10

KW-0902

Two-component regulatory system

4 of 13

2.04

2.47

8.24e-06

KW-0067

ATP-binding

7 of 299

0.92

0.85

0.00017

KW-0175

Coiled coil

8 of 414

0.84

0.77

0.00011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

9 of 20

2.21

6.37

1.39e-15

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

9 of 21

2.19

6.3

1.39e-15

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 23

2.15

6.16

1.39e-15

IPR005467

Histidine kinase domain

9 of 26

2.09

5.89

2.44e-15

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 32

2.0

5.38

9.65e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 21

2.19

6.59

1.66e-16

SM00387

Histidine kinase-like ATPases

9 of 32

2.0

5.55

2.02e-15

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

5 of 10

2.25

3.99

5.91e-09

SM00091

PAS domain

6 of 23

1.97

3.73

1.87e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 11

1.81

0.93

0.0151

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