STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kuKu protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (302 aa)    
Predicted Functional Partners:
ORW56150.1
ATP-dependent DNA ligase; Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.985
ligC
ATP-dependent DNA ligase; Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.941
ORW50659.1
ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.907
ORW49420.1
DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.881
ORW56140.1
ATP-dependent DNA helicase PcrA; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.879
ligB
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
  
 0.829
ORW56153.1
Ribokinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.810
ORW60992.1
ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.748
ORW56413.1
Mannitol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.739
ORW60659.1
ATP-dependent DNA helicase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the helicase family. UvrD subfamily.
     
 0.733
Your Current Organism:
Mycobacterium parmense
NCBI taxonomy Id: 185642
Other names: CCUG 50998, CIP 107385, DSM 44553, JCM 14742, M. parmense, Mycobacterium parmense Fanti et al. 2004
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.