node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFG38577.1 | SFG40096.1 | SAMN05660282_00754 | SAMN05660282_00810 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | Branched-chain amino acid aminotransferase. | 0.812 |
SFG38577.1 | SFG62948.1 | SAMN05660282_00754 | SAMN05660282_01442 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | Alanine-synthesizing transaminase. | 0.712 |
SFG38577.1 | ilvA | SAMN05660282_00754 | SAMN05660282_00749 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.827 |
SFG38577.1 | ldh | SAMN05660282_00754 | SAMN05660282_01965 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.853 |
SFG38577.1 | leuA | SAMN05660282_00754 | SAMN05660282_02168 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.840 |
SFG40096.1 | SFG38577.1 | SAMN05660282_00810 | SAMN05660282_00754 | Branched-chain amino acid aminotransferase. | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.812 |
SFG40096.1 | SFG53064.1 | SAMN05660282_00810 | SAMN05660282_01171 | Branched-chain amino acid aminotransferase. | Homoserine dehydrogenase. | 0.871 |
SFG40096.1 | SFG59405.1 | SAMN05660282_00810 | SAMN05660282_01325 | Branched-chain amino acid aminotransferase. | Dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.788 |
SFG40096.1 | SFG62948.1 | SAMN05660282_00810 | SAMN05660282_01442 | Branched-chain amino acid aminotransferase. | Alanine-synthesizing transaminase. | 0.813 |
SFG40096.1 | ilvA | SAMN05660282_00810 | SAMN05660282_00749 | Branched-chain amino acid aminotransferase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.971 |
SFG40096.1 | ilvC | SAMN05660282_00810 | SAMN05660282_01086 | Branched-chain amino acid aminotransferase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.910 |
SFG40096.1 | ilvD | SAMN05660282_00810 | SAMN05660282_00319 | Branched-chain amino acid aminotransferase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.996 |
SFG40096.1 | ldh | SAMN05660282_00810 | SAMN05660282_01965 | Branched-chain amino acid aminotransferase. | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.812 |
SFG40096.1 | leuA | SAMN05660282_00810 | SAMN05660282_02168 | Branched-chain amino acid aminotransferase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.971 |
SFG40096.1 | thrB | SAMN05660282_00810 | SAMN05660282_01170 | Branched-chain amino acid aminotransferase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.839 |
SFG53064.1 | SFG40096.1 | SAMN05660282_01171 | SAMN05660282_00810 | Homoserine dehydrogenase. | Branched-chain amino acid aminotransferase. | 0.871 |
SFG53064.1 | SFG62948.1 | SAMN05660282_01171 | SAMN05660282_01442 | Homoserine dehydrogenase. | Alanine-synthesizing transaminase. | 0.465 |
SFG53064.1 | ilvA | SAMN05660282_01171 | SAMN05660282_00749 | Homoserine dehydrogenase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.909 |
SFG53064.1 | thrB | SAMN05660282_01171 | SAMN05660282_01170 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
SFG59405.1 | SFG40096.1 | SAMN05660282_01325 | SAMN05660282_00810 | Dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Branched-chain amino acid aminotransferase. | 0.788 |