node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFG37708.1 | SFG55676.1 | SAMN05660282_00718 | SAMN05660282_01224 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Glycine radical. | 0.831 |
SFG37708.1 | SFG55702.1 | SAMN05660282_00718 | SAMN05660282_01225 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Formate C-acetyltransferase. | 0.831 |
SFG37708.1 | leuA | SAMN05660282_00718 | SAMN05660282_02168 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.822 |
SFG37708.1 | leuC | SAMN05660282_00718 | SAMN05660282_01066 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.818 |
SFG37708.1 | leuD | SAMN05660282_00718 | SAMN05660282_01065 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.820 |
SFG50217.1 | leuA | SAMN05660282_01067 | SAMN05660282_02168 | Transcriptional regulator, IclR family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.430 |
SFG50217.1 | leuC | SAMN05660282_01067 | SAMN05660282_01066 | Transcriptional regulator, IclR family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.940 |
SFG50217.1 | leuD | SAMN05660282_01067 | SAMN05660282_01065 | Transcriptional regulator, IclR family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.876 |
SFG50710.1 | ilvC | SAMN05660282_01087 | SAMN05660282_01086 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SFG50710.1 | ilvD | SAMN05660282_01087 | SAMN05660282_00319 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.922 |
SFG50710.1 | leuA | SAMN05660282_01087 | SAMN05660282_02168 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.954 |
SFG50710.1 | leuB | SAMN05660282_01087 | SAMN05660282_01075 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.977 |
SFG50710.1 | leuC | SAMN05660282_01087 | SAMN05660282_01066 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.785 |
SFG50710.1 | leuD | SAMN05660282_01087 | SAMN05660282_01065 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.845 |
SFG55676.1 | SFG37708.1 | SAMN05660282_01224 | SAMN05660282_00718 | Glycine radical. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.831 |
SFG55676.1 | SFG55702.1 | SAMN05660282_01224 | SAMN05660282_01225 | Glycine radical. | Formate C-acetyltransferase. | 0.998 |
SFG55676.1 | leuD | SAMN05660282_01224 | SAMN05660282_01065 | Glycine radical. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.822 |
SFG55702.1 | SFG37708.1 | SAMN05660282_01225 | SAMN05660282_00718 | Formate C-acetyltransferase. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.831 |
SFG55702.1 | SFG55676.1 | SAMN05660282_01225 | SAMN05660282_01224 | Formate C-acetyltransferase. | Glycine radical. | 0.998 |
SFG55702.1 | leuD | SAMN05660282_01225 | SAMN05660282_01065 | Formate C-acetyltransferase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.822 |