M5FSI3_DACPD protein (Dacryopinax primogenitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

M5FSI3_DACPD

ERCC4 domain-containing protein. (348 aa)

Predicted Functional Partners:

M5FX88_DACPD

0.919

M5FZC5_DACPD

0.748

M5GG09_DACPD

0.633

M5GEV4_DACPD

0.625

M5FZE0_DACPD

0.622

M5GA59_DACPD

0.593

M5GCJ3_DACPD

0.584

M5G8I2_DACPD

0.561

M5GDD8_DACPD

0.561

M5G1S7_DACPD

0.554

Your Current Organism:

Dacryopinax primogenitus

NCBI taxonomy Id: 1858805
Other names: D. primogenitus, DJM 731, DJM-731 SS1, Dacryopinax primogenitus D. J. McLaughlin & E. G. McLaughlin, 2016, Dacryopinax sp. DJM-731 SS1, Dacryopinax sp. MIN 862738, MIN 929365

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
M5FSI3_DACPD	M5FX88_DACPD	M5FSI3	M5FX88	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.919
M5FSI3_DACPD	M5FZC5_DACPD	M5FSI3	M5FZC5	ERCC4 domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.748
M5FSI3_DACPD	M5FZE0_DACPD	M5FSI3	M5FZE0	ERCC4 domain-containing protein.	Uncharacterized protein.	0.622
M5FSI3_DACPD	M5G1S7_DACPD	M5FSI3	M5G1S7	ERCC4 domain-containing protein.	Small nuclear ribo protein F.	0.554
M5FSI3_DACPD	M5G8I2_DACPD	M5FSI3	M5G8I2	ERCC4 domain-containing protein.	Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.	0.561
M5FSI3_DACPD	M5GA59_DACPD	M5FSI3	M5GA59	ERCC4 domain-containing protein.	Chromatin assembly factor 1 subunit C.	0.593
M5FSI3_DACPD	M5GCJ3_DACPD	M5FSI3	M5GCJ3	ERCC4 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.584
M5FSI3_DACPD	M5GDD8_DACPD	M5FSI3	M5GDD8	ERCC4 domain-containing protein.	PIN domain-like protein.	0.561
M5FSI3_DACPD	M5GEV4_DACPD	M5FSI3	M5GEV4	ERCC4 domain-containing protein.	DNA polymerase.	0.625
M5FSI3_DACPD	M5GG09_DACPD	M5FSI3	M5GG09	ERCC4 domain-containing protein.	Uncharacterized protein.	0.633
M5FX88_DACPD	M5FSI3_DACPD	M5FX88	M5FSI3	ERCC4 domain-containing protein.	ERCC4 domain-containing protein.	0.919
M5FX88_DACPD	M5FZC5_DACPD	M5FX88	M5FZC5	ERCC4 domain-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.999
M5FX88_DACPD	M5GDD8_DACPD	M5FX88	M5GDD8	ERCC4 domain-containing protein.	PIN domain-like protein.	0.910
M5FX88_DACPD	M5GEV4_DACPD	M5FX88	M5GEV4	ERCC4 domain-containing protein.	DNA polymerase.	0.730
M5FZC5_DACPD	M5FSI3_DACPD	M5FZC5	M5FSI3	P-loop containing nucleoside triphosphate hydrolase protein.	ERCC4 domain-containing protein.	0.748
M5FZC5_DACPD	M5FX88_DACPD	M5FZC5	M5FX88	P-loop containing nucleoside triphosphate hydrolase protein.	ERCC4 domain-containing protein.	0.999
M5FZC5_DACPD	M5GCJ3_DACPD	M5FZC5	M5GCJ3	P-loop containing nucleoside triphosphate hydrolase protein.	ANK_REP_REGION domain-containing protein.	0.635
M5FZC5_DACPD	M5GDD8_DACPD	M5FZC5	M5GDD8	P-loop containing nucleoside triphosphate hydrolase protein.	PIN domain-like protein.	0.912
M5FZC5_DACPD	M5GEV4_DACPD	M5FZC5	M5GEV4	P-loop containing nucleoside triphosphate hydrolase protein.	DNA polymerase.	0.933
M5FZE0_DACPD	M5FSI3_DACPD	M5FZE0	M5FSI3	Uncharacterized protein.	ERCC4 domain-containing protein.	0.622

page 1 of 3

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046874

Quinolinate metabolic process

4 of 4

3.26

4.1

3.62e-08

GO:0006569

Tryptophan catabolic process

4 of 8

2.96

3.75

1.28e-07

GO:0042537

Benzene-containing compound metabolic process

4 of 15

2.69

3.5

2.86e-07

GO:0009435

NAD biosynthetic process

4 of 16

2.66

3.49

2.86e-07

GO:0043420

Anthranilate metabolic process

3 of 3

3.26

3.31

1.01e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36766803

(2023) Kynurenine Pathway in Diabetes Mellitus-Novel Pharmacological Target?

5 of 20

2.66

3.87

5.02e-08

PMID:31673160

(2020) NAD(+) homeostasis in renal health and disease.

5 of 24

2.58

3.81

5.60e-08

PMID:27374990

(2016) NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy.

5 of 48

2.28

3.06

8.97e-07

PMID:36325027

(2022) Species Differences in Tryptophan Metabolism and Disposition.

4 of 14

2.72

3.06

2.09e-06

PMID:24043287

(2014) Changes in plasma kynurenic acid concentration in septic shock patients undergoing continuous veno-venous haemofiltration.

3 of 9

2.79

1.93

0.00030

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5979

Tryptophan catabolic process

5 of 10

2.96

5.21

2.22e-10

CL:5980

Anthranilate metabolic process, and cysteine-S-conjugate beta-lyase activity

4 of 5

3.17

4.41

8.98e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00380

Tryptophan metabolism

5 of 37

2.39

4.19

4.60e-09

cfa01100

Metabolic pathways

8 of 1220

1.08

1.22

4.22e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

CFA-71240

Tryptophan catabolism

4 of 11

2.82

3.77

1.03e-07

CFA-71291

Metabolism of amino acids and derivatives

5 of 237

1.59

1.69

8.24e-05

CFA-1430728

Metabolism

7 of 1516

0.93

0.74

0.0018

WikiPathways

pathway

description

count in network

strength

signal

false discovery rate

WP1126

Tryptophan metabolism

4 of 35

2.32

3.49

1.20e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032117

Horsetail-astral microtubule array

3 of 4

3.14

2.82

7.68e-06

GOCC:0005819

Spindle

4 of 152

1.68

1.51

0.00049

GOCC:0099080

Supramolecular complex

4 of 573

1.11

0.55

0.0484

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0662

Pyridine nucleotide biosynthesis

3 of 7

2.9

2.86

5.92e-06

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About