STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OIQ27618.13-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (364 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.851
OIQ27035.1
Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.828
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 
 0.794
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.792
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
    
 0.734
OIQ28671.1
Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.714
OIQ30601.1
Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.704
OIQ29505.1
Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transketolase family.
  
  
 0.695
OIQ29481.1
Aminodeoxychorismate/anthranilate synthase component II; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.675
OIQ27807.1
3-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.634
Your Current Organism:
Alphaproteobacteria bacterium MedPESWcel
NCBI taxonomy Id: 1860092
Other names: A. bacterium MedPE-SWcel, Alphaproteobacteria bacterium MedPE-SWcel
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.