Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFA49737.1
VWA-like domain. (137 aa)
Predicted Functional Partners:
SFA49742.1
EamA-like transporter family protein.
0.539
Your Current Organism:
Parageobacillus thermantarcticus
NCBI taxonomy Id: 186116 Other names: BGSC 20A1, Bacillus thermantarcticus, Bacillus thermantarcticus corrig. Nicolaus et al. 2002, Bacillus thermoantarcticus, DSM 9572, Geobacillus sp. R-35644, Geobacillus thermantarcticus, Geobacillus thermantarcticus (Nicolaus et al. 2002) Coorevits et al. 2012, LMG 23032, LMG:23032, P. thermantarcticus, strain M1, strain R-35644