STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa)    
Predicted Functional Partners:
SFA51740.1
Homoserine dehydrogenase.
 
 0.999
SFA51743.1
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
 0.997
SFA50782.1
Homocysteine S-methyltransferase.
 
  
 0.929
SFA50778.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.917
purM
Phosphoribosylformylglycinamidine cyclo-ligase.
 
    
 0.912
SFA48195.1
D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.886
SFA56670.1
D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.886
SFA49975.1
Aspartate kinase; Belongs to the aspartokinase family.
 
 0.846
SFA41613.1
Aspartate kinase; Belongs to the aspartokinase family.
 
 0.843
SFA39054.1
Aspartate kinase; Belongs to the aspartokinase family.
  
 0.808
Your Current Organism:
Parageobacillus thermantarcticus
NCBI taxonomy Id: 186116
Other names: BGSC 20A1, Bacillus thermantarcticus, Bacillus thermantarcticus corrig. Nicolaus et al. 2002, Bacillus thermoantarcticus, DSM 9572, Geobacillus sp. R-35644, Geobacillus thermantarcticus, Geobacillus thermantarcticus (Nicolaus et al. 2002) Coorevits et al. 2012, LMG 23032, LMG:23032, P. thermantarcticus, strain M1, strain R-35644
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