node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0027 | PF0028 | PF0027 | PF0028 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Putative acetyl transferase; Function Code: 16.0 Unknown. | 0.433 |
PF0027 | PF0031 | PF0027 | PF0031 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Threonine synthase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family. | 0.427 |
PF0027 | PF0265 | PF0027 | PF0265 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.486 |
PF0027 | PF0462 | PF0027 | PF0462 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.445 |
PF0027 | PF0476 | PF0027 | PF0476 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Competence-damage inducible protein, putative; Function Code: 16 Unknown:; Belongs to the CinA family. | 0.484 |
PF0027 | cca | PF0027 | PF0026 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | tRNA nucleotidyltransferase (cca); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | 0.701 |
PF0027 | rnr | PF0027 | PF0440 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase class-2 family. | 0.604 |
PF0027 | rtc | PF0027 | PF1549 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | RNA-3'-phosphate cyclase; Catalyzes the GTP-dependent conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing; Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily. | 0.680 |
PF0027 | rtcB | PF0027 | PF1615 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family. | 0.824 |
PF0027 | trpS | PF0027 | PF0241 | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | tryptophanyl-tRNA synthetase; Function Code: 13.1 Translation: Amino acyl tRNA synthetases; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.548 |
PF0028 | PF0027 | PF0028 | PF0027 | Putative acetyl transferase; Function Code: 16.0 Unknown. | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.433 |
PF0028 | PF0031 | PF0028 | PF0031 | Putative acetyl transferase; Function Code: 16.0 Unknown. | Threonine synthase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family. | 0.791 |
PF0031 | PF0027 | PF0031 | PF0027 | Threonine synthase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family. | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.427 |
PF0031 | PF0028 | PF0031 | PF0028 | Threonine synthase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family. | Putative acetyl transferase; Function Code: 16.0 Unknown. | 0.791 |
PF0265 | PF0027 | PF0265 | PF0027 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.486 |
PF0462 | PF0027 | PF0462 | PF0027 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.445 |
PF0462 | PF0476 | PF0462 | PF0476 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Competence-damage inducible protein, putative; Function Code: 16 Unknown:; Belongs to the CinA family. | 0.716 |
PF0476 | PF0027 | PF0476 | PF0027 | Competence-damage inducible protein, putative; Function Code: 16 Unknown:; Belongs to the CinA family. | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.484 |
PF0476 | PF0462 | PF0476 | PF0462 | Competence-damage inducible protein, putative; Function Code: 16 Unknown:; Belongs to the CinA family. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.716 |
cca | PF0027 | PF0026 | PF0027 | tRNA nucleotidyltransferase (cca); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. | Putative integral membrane transport protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, ligates 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. Ligase activity requires GTP, but GTP hydrolysis is not required for the reaction, which is reversible. Ligase activity is weak compared to the phosphodiesterase activity; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.701 |