node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0295 | dphB | PF0295 | PF0595 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.913 |
PF0295 | fusA | PF0295 | PF2012 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] | 0.698 |
PF0295 | yjgF | PF0295 | PF0668 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Hypothetical protein; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis; Belongs to the RutC family. | 0.766 |
PF0596 | dphB | PF0596 | PF0595 | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.797 |
PF0828 | PF1063 | PF0828 | PF1063 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.441 |
PF0828 | dphB | PF0828 | PF0595 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.902 |
PF0828 | eif2b | PF0828 | PF0481 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Translation initiation factor eIF-2, subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. | 0.418 |
PF0828 | fusA | PF0828 | PF2012 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] | 0.750 |
PF0828 | guaAB | PF0828 | PF1516 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.756 |
PF0828 | yjgF | PF0828 | PF0668 | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | Hypothetical protein; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in the low water environment of the cell. It catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia. It is required for the detoxification of reactive intermediates of IlvA due to their highly nucleophilic abilities. Involved in the isoleucine biosynthesis; Belongs to the RutC family. | 0.648 |
PF1063 | PF0828 | PF1063 | PF0828 | Hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | 0.441 |
PF1063 | dphB | PF1063 | PF0595 | Hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.951 |
PF1063 | eif2b | PF1063 | PF0481 | Hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor eIF-2, subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. | 0.577 |
PF1063 | fusA | PF1063 | PF2012 | Hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Elongation factor 2 (EF-2); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] | 0.982 |
PF1063 | moaA | PF1063 | PF0090 | Hypothetical protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Molybdenum cofactor biosynthesis protein; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. | 0.613 |
PF1415 | dphB | PF1415 | PF0595 | Met-10+ protein; Function Code: 16 Unknown:. | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.701 |
PF1415 | eif2b | PF1415 | PF0481 | Met-10+ protein; Function Code: 16 Unknown:. | Translation initiation factor eIF-2, subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. | 0.544 |
dphB | PF0295 | PF0595 | PF0295 | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | 0.913 |
dphB | PF0596 | PF0595 | PF0596 | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. | 0.797 |
dphB | PF0828 | PF0595 | PF0828 | Hydrogenase expression/formation protein; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | N-type ATP pyrophosphatase superfamily; Function Code: 16.0 Unknown. | 0.902 |