node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCA55449.1 | SCA55608.1 | MTBPR1_100090 | MTBPR1_110047 | 3'-5' exonuclease. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.950 |
SCA55449.1 | hrpB | MTBPR1_100090 | MTBPR1_90032 | 3'-5' exonuclease. | ATP-dependent RNA helicase HrpB. | 0.949 |
SCA55449.1 | rnr | MTBPR1_100090 | MTBPR1_60091 | 3'-5' exonuclease. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.981 |
SCA55449.1 | rph | MTBPR1_100090 | MTBPR1_130026 | 3'-5' exonuclease. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.988 |
SCA55449.1 | rpsA | MTBPR1_100090 | MTBPR1_180029 | 3'-5' exonuclease. | 30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.968 |
SCA55449.1 | rpsD | MTBPR1_100090 | MTBPR1_100076 | 3'-5' exonuclease. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.971 |
SCA55449.1 | rpsK | MTBPR1_100090 | MTBPR1_10523 | 3'-5' exonuclease. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.969 |
SCA55608.1 | SCA55449.1 | MTBPR1_110047 | MTBPR1_100090 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3'-5' exonuclease. | 0.950 |
SCA55608.1 | hrpB | MTBPR1_110047 | MTBPR1_90032 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | ATP-dependent RNA helicase HrpB. | 0.744 |
SCA55608.1 | rnd | MTBPR1_110047 | MTBPR1_10598 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. | 0.950 |
SCA55608.1 | rnr | MTBPR1_110047 | MTBPR1_60091 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.845 |
SCA55608.1 | rph | MTBPR1_110047 | MTBPR1_130026 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.926 |
SCA55608.1 | rpsA | MTBPR1_110047 | MTBPR1_180029 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. | 0.967 |
SCA55608.1 | rpsD | MTBPR1_110047 | MTBPR1_100076 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. | 0.999 |
SCA55608.1 | rpsK | MTBPR1_110047 | MTBPR1_10523 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.999 |
SCA55831.1 | rnr | MTBPR1_130027 | MTBPR1_60091 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.717 |
SCA55831.1 | rph | MTBPR1_130027 | MTBPR1_130026 | Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.996 |
dnaG | rph | MTBPR1_100010 | MTBPR1_130026 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.948 |
dnaG | rpsK | MTBPR1_100010 | MTBPR1_10523 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. | 0.435 |
hrpB | SCA55449.1 | MTBPR1_90032 | MTBPR1_100090 | ATP-dependent RNA helicase HrpB. | 3'-5' exonuclease. | 0.949 |