Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KHD79222.1dephospho-CoA kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)    
Predicted Functional Partners:
KHD77013.1
Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
  0.959
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 
   
  0.921
KHD77545.1
Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
  0.907
KHD72675.1
Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPRTase family.
  
 0.904
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 0.713
KHD74833.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.713
KHD74544.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.713
KHD74277.1
Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.713
KHD74583.1
Phosphatidylinositol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.703
KHD79184.1
Chorismate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.695
Your Current Organism:
Actinoplanes utahensis
NCBI taxonomy Id: 1869
Other names: A. utahensis, ATCC 14539, DSM 43147, IFO 13244, IMSNU 20044, JCM 3122, NBRC 13244, NRRL B-16727, VKM Ac-674
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