STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KHD78995.1Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)    
Predicted Functional Partners:
KHD78073.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.969
KHD78853.1
Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
  
  0.945
KHD72408.1
Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
  0.945
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.933
KHD76509.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.932
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.932
KHD79076.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.
    
  0.931
KHD74164.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.931
KHD73891.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.931
KHD79268.1
Serine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.923
Your Current Organism:
Actinoplanes utahensis
NCBI taxonomy Id: 1869
Other names: A. utahensis, ATCC 14539, DSM 43147, IFO 13244, IMSNU 20044, JCM 3122, NBRC 13244, NRRL B-16727, VKM Ac-674
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