STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KHD78066.1Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.984
KHD72664.1
Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.972
KHD74307.1
Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.971
KHD72665.1
Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.957
KHD72364.1
Purine nucleoside phosphorylase DeoD-type; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.948
KHD73891.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
  0.934
KHD79076.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.
    
  0.924
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.920
KHD73052.1
Deoxyuridine 5'-triphosphate nucleotidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.920
KHD77578.1
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
 
  
 0.908
Your Current Organism:
Actinoplanes utahensis
NCBI taxonomy Id: 1869
Other names: A. utahensis, ATCC 14539, DSM 43147, IFO 13244, IMSNU 20044, JCM 3122, NBRC 13244, NRRL B-16727, VKM Ac-674
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