Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (344 aa)    
Predicted Functional Partners:
KHD75970.1
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
 0.999
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.997
KHD73814.1
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.991
KHD78761.1
Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.987
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.979
KHD75203.1
uroporphyrin-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.969
KHD72588.1
uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.960
KHD73871.1
Bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.954
KHD72589.1
Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.
 
 
 0.948
KHD76089.1
Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.930
Your Current Organism:
Actinoplanes utahensis
NCBI taxonomy Id: 1869
Other names: A. utahensis, ATCC 14539, DSM 43147, IFO 13244, IMSNU 20044, JCM 3122, NBRC 13244, NRRL B-16727, VKM Ac-674
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