Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KHD75880.1NAD(P)H dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the WrbA family. (200 aa)    
Predicted Functional Partners:
KHD78708.1
Quinone oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.895
menG
Ubiquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
  0.895
KHD77844.1
NADPH-quinone reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.827
KHD77920.1
NADPH-dependent FMN reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.783
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.767
KHD75882.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.762
KHD75972.1
Glycoside hydrolase family 13; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.733
KHD76335.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
    0.620
KHD78946.1
Peptidase M23B; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.619
KHD78703.1
Catalase; Serves to protect cells from the toxic effects of hydrogen peroxide.
  
  
 0.527
Your Current Organism:
Actinoplanes utahensis
NCBI taxonomy Id: 1869
Other names: A. utahensis, ATCC 14539, DSM 43147, IFO 13244, IMSNU 20044, JCM 3122, NBRC 13244, NRRL B-16727, VKM Ac-674
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