OFE18899.1 protein (Humibacillus sp. DSM 29435)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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[Homology]

Score

OFE18899.1

ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)

Predicted Functional Partners:

OFE18898.1

0.993

OFE18900.1

0.987

OFE18894.1

0.552

OFE18895.1

0.552

OFE18896.1

0.552

OFE18897.1

0.552

OFE17699.1

0.455

Your Current Organism:

Humibacillus sp. DSM 29435

NCBI taxonomy Id: 1869167
Other names: H. sp. DSM 29435

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OFE17699.1	OFE18898.1	BA895_14480	BA895_01675	Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.416
OFE17699.1	OFE18899.1	BA895_14480	BA895_01680	Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.455
OFE17699.1	OFE18900.1	BA895_14480	BA895_01685	Glutamate synthase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.424
OFE18894.1	OFE18895.1	BA895_01655	BA895_01660	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18894.1	OFE18896.1	BA895_01655	BA895_01665	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18894.1	OFE18897.1	BA895_01655	BA895_01670	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18894.1	OFE18898.1	BA895_01655	BA895_01675	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18894.1	OFE18899.1	BA895_01655	BA895_01680	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18894.1	OFE18900.1	BA895_01655	BA895_01685	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18895.1	OFE18894.1	BA895_01660	BA895_01655	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18895.1	OFE18896.1	BA895_01660	BA895_01665	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18895.1	OFE18897.1	BA895_01660	BA895_01670	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18895.1	OFE18898.1	BA895_01660	BA895_01675	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18895.1	OFE18899.1	BA895_01660	BA895_01680	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18895.1	OFE18900.1	BA895_01660	BA895_01685	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18896.1	OFE18894.1	BA895_01665	BA895_01655	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18896.1	OFE18895.1	BA895_01665	BA895_01660	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	PPOX class F420-dependent enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
OFE18896.1	OFE18897.1	BA895_01665	BA895_01670	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.958
OFE18896.1	OFE18898.1	BA895_01665	BA895_01675	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
OFE18896.1	OFE18899.1	BA895_01665	BA895_01680	Gluconate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.879

expected number of edges:

17

PPI enrichment p-value:

3.25e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071103

DNA conformation change

4 of 29

1.74

1.79

0.00011

GO:0006260

DNA replication

4 of 34

1.67

1.65

0.00019

GO:0006259

DNA metabolic process

7 of 144

1.29

1.54

6.62e-06

GO:0090304

Nucleic acid metabolic process

10 of 336

1.07

1.32

1.15e-07

GO:0044260

Cellular macromolecule metabolic process

8 of 367

0.94

0.91

5.24e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140097

Catalytic activity, acting on DNA

7 of 95

1.47

2.09

3.45e-07

GO:0140640

Catalytic activity, acting on a nucleic acid

10 of 202

1.29

2.04

4.51e-10

GO:0004527

Exonuclease activity

4 of 22

1.86

1.98

5.84e-05

GO:0008408

3-5 exonuclease activity

3 of 7

2.23

1.92

0.00021

GO:0003887

DNA-directed DNA polymerase activity

3 of 13

1.96

1.61

0.00061

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030894

Replisome

3 of 7

2.23

1.94

0.00019

GO:0043590

Bacterial nucleoid

2 of 8

2.0

1.16

0.0059

GO:0032991

Protein-containing complex

6 of 200

1.08

1.03

0.00019

GO:0140535

Intracellular protein-containing complex

2 of 21

1.58

0.8

0.0226

GO:1902494

Catalytic complex

3 of 91

1.12

0.65

0.0226

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:587

Mismatch repair, and DNA replication

8 of 38

1.92

4.26

1.24e-11

CL:594

Mixed, incl. UvrD-like DNA helicase, C-terminal, and DNA replication

5 of 13

2.18

3.5

5.74e-08

CL:598

Mixed, incl. Replisome, and 5-3 exonuclease

4 of 6

2.42

3.21

6.33e-07

CL:638

DNA polymerase activity, and Primosome

3 of 12

2.0

1.63

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03030

DNA replication

5 of 43

1.66

2.1

7.58e-06

map03440

Homologous recombination

3 of 39

1.49

0.94

0.0087

map03430

Mismatch repair

3 of 41

1.46

0.93

0.0087

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005694

Chromosome

3 of 32

1.57

1.05

0.0055

GOCC:0030894

Replisome

2 of 7

2.06

1.01

0.0121

GOCC:1902494

Catalytic complex

6 of 244

0.99

0.8

0.0017

GOCC:0032993

protein-DNA complex

3 of 61

1.29

0.74

0.0191

GOCC:0032991

Protein-containing complex

9 of 605

0.77

0.67

0.00025

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0235

DNA replication

3 of 14

1.93

1.41

0.0016

KW-0239

DNA-directed DNA polymerase

2 of 5

2.2

1.18

0.0061

KW-0548

Nucleotidyltransferase

3 of 30

1.6

1.11

0.0042

KW-0238

DNA-binding

6 of 247

0.98

0.8

0.0016

KW-0819

tRNA processing

2 of 14

1.75

0.8

0.0274

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