STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (451 aa)    
Predicted Functional Partners:
Mlg_0002
KEGG: xoo:XOO0002 DNA polymerase III beta chain; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III, beta chain.
 
 0.993
Mlg_0003
TIGRFAM: DNA replication and repair protein RecF; PFAM: SMC domain protein; KEGG: sdn:Sden_0003 DNA replication and repair protein RecF.
  
 0.961
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 0.795
Mlg_0587
Transcriptional regulator, XRE family; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.
   
 
 0.773
Mlg_2612
TIGRFAM: twin-arginine translocation protein, TatA/E family subunit; PFAM: sec-independent translocation protein mttA/Hcf106; KEGG: hch:HCH_01076 sec-independent protein secretion pathway components.
      
 0.771
Mlg_2836
PFAM: ribulose bisphosphate carboxylase, large chain; KEGG: mca:MCA2743 ribulose bisphosphate carboxylase, large subunit.
      
 0.771
Mlg_2877
TIGRFAM: parB-like partition proteins; PFAM: ParB domain protein nuclease; KEGG: noc:Noc_3082 ParB-like partition protein.
 
  
 0.690
rpoB
DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.689
Mlg_1508
KEGG: csa:Csal_1460 recombination protein RecR; TIGRFAM: recombination protein RecR; PFAM: RecR protein; TOPRIM domain protein; SMART: Toprim sub domain protein.
 
  
 0.677
Mlg_1712
DNA translocase FtsK; PFAM: cell divisionFtsK/SpoIIIE; KEGG: sde:Sde_1693 cell division protein FtsK.
  
  
 0.661
Your Current Organism:
Alkalilimnicola ehrlichii
NCBI taxonomy Id: 187272
Other names: A. ehrlichii MLHE-1, Alkalilimnicola ehrlichii MLHE-1, Alkalilimnicola ehrlichii str. MLHE-1, Alkalilimnicola ehrlichii strain MLHE-1, Mono Lake Gammaproteobacter MLHE-1, arsenite-oxidizing bacterium MLHE-1, gamma proteobacterium MLHE-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.