Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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BN69_1995Heat shock protein Hsp20; Belongs to the small heat shock protein (HSP20) family. (141 aa)    
Predicted Functional Partners:
clpB
Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.708
BN69_1544
Tetratricopeptide repeat (TPR)-containing protein.
  
 
 0.708
BN69_3150
ATP-dependent Clp protease, ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family.
  
 
 0.708
BN69_0652
Glutamine synthetase.
    
 
 0.689
dnaK
Chaperone protein DnaK, Heat shock 70 kDa protein (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.652
BN69_2014
PfkB family carbohydrate kinase.
 
  
 0.584
htpG
Chaperone protein HtpG; Molecular chaperone. Has ATPase activity.
  
 
 0.568
BN69_1996
Conserved hypothetical protein.
       0.545
BN69_0745
Conserved hypothetical protein.
  
     0.522
grpE
Protein grpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
  
 
 0.493
Your Current Organism:
Methylocystis sp. SC2
NCBI taxonomy Id: 187303
Other names: M. sp. SC2
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