STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypBHydrogenase accessory protein HypB; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)    
Predicted Functional Partners:
hypA
Hydrogenase maturation nickel metallochaperone HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.993
hypC
Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.992
hypD
Hydrogenase formation protein HypD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family.
 
  
 0.992
hypE
Hydrogenase expression/formation protein HypE; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.961
ureF
Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
  
 
 0.953
hypF
Carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.924
ureE1
Urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.
  
 
 0.898
AQQ05112.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.861
ureD
Urease accessory protein; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
  
 
 0.853
hoxH
Ni/Fe hydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.848
Your Current Organism:
Labrenzia aggregata
NCBI taxonomy Id: 187304
Other names: ATCC 25650, Agrobacterium aggregatum, DSM 13394, IAM 12614, JCM 20685, L. aggregata, LMG 122, LMG:122, NBRC 16684, NCIMB 2208, Stappia aggregata, strain B1
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