STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MTH_1027CDP-diacylglycerol-serine O-phosphatidyltransferase; Involved in the lipid biosynthesis. Catalyzes the formation of unsaturated archaetidylserine from CDP-unsaturated archaeol and L- serine. Activity with ester-linked substrate analogs containing straight aliphatic chains (typical bacterial substrates) is two to three times higher than that with the corresponding ether-type substrate (typical archaeal substrates). Both enantiomers of CDP- unsaturated archaeols with ether-linked geranylgeranyl chains and CDP- saturated archaeol with ether-linked phytanyl chains are similarly active. The [...] (233 aa)    
Predicted Functional Partners:
asd
Phosphatidylserine decarboxylase; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
 
  
 0.957
carS
Conserved protein; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids.
 
  
  0.948
MTH_1028
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:C64404 AC:C64404, p()=0.24, pid=12%.
       0.803
MTH_1029
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:LPDGA1 AC:A60940:A03092, p()=0.995, pid=08%.
       0.636
mptD
Conserved protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family.
       0.620
MTH_1030
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:SECE_RICPR AC:P50054, p()=0.998, pid=04%.
       0.582
MTH_1691
Conserved protein; Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn- glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3- phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
  
  
 0.565
MTH_1024
Rod shape-determining protein; Function Code:11.04 - Cell envelope, Murein sacculus and peptidoglycan; similar to, gp:GI:g142855, p()=4E-46, pid=29%.
 
     0.541
MTH_1179
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:e214882:g1132531, p()=2.7E-09, pid=14%.
 
    0.483
MTH_1022
Biopolymer transport protein; Function Code:12.01 - Cell Processes, Transport of amino acids--peptides and amines; similar to, gp:GI:g1001752, p()=4.6E-13, pid=19%.
 
     0.479
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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