Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_1111Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64466 AC:A64466, p()=6.3E-25, pid=24%. (273 aa)    
Predicted Functional Partners:
cobS
Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
     
 0.874
MTH_1113
Conserved protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.
       0.868
MTH_1109
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64473 AC:B64473, p()=2.2E-45, pid=27%; Belongs to the LarC family.
       0.680
MTH_1110
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64455 AC:C64455, p()=4.7E-20, pid=30%; To M.jannaschii MJ1244 and MJ1245.
       0.595
hisC
Histidinol-phosphate aminotransferase; Function Code:5.10 - L-Amino Acid Metabolism, Histidine metabolism; similar to, pir:LN:C64419 AC:C64419, p()=2.6E-97, pid=46%.
     
 0.586
queC
Conserved protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
       0.582
cobD
Cobalamin biosynthesis protein B; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
     
 0.581
MTH_1152
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:e238770:g1296941, p()=3.5E-63, pid=53%.
       0.569
MTH_1426
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64499 AC:E64499, p()=3.9E-48, pid=34%; Belongs to the UPF0284 family.
       0.569
MTH_1691
Conserved protein; Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn- glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3- phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
     
 0.569
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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