STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
comEPhosphonopyruvate decarboxylase related protein; Involved in the biosynthesis of the coenzyme M (2- mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. (185 aa)    
Predicted Functional Partners:
comD
Phosphonopyruvate decarboxylase related protein; Involved in the biosynthesis of the coenzyme M (2- mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde; Belongs to the ComD family.
  
 0.999
comC
Malate dehydrogenase; Catalyzes the reduction of sulfopyruvate to (R)-sulfolactate. Involved in the biosynthesis of both coenzyme M (with (R)-sulfolactate) and methanopterin (with alpha-ketoglutarate) (By similarity).
    
 0.998
mrtD
Methyl coenzyme M reductase II, D protein; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:MCRW_METTH AC:Q50485, p()=1.6E-65, pid=79%.
      
 0.996
frhG
Coenzyme F420-reducing hydrogenase, gamma subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the FrhG family.
      
 0.994
comB
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64442 AC:C64442, p()=1.4E-20, pid=31%.
      
 0.931
mcrC
Methyl coenzyme M reductase I, C protein; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:g517429 LN:MTU10036, p()=1.3E-102, pid=99%.
      
 0.911
mcrD
Methyl coenzyme M reductase I, D protein; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, gp:GI:g517428 LN:MTU10036, p()=6.7E-60, pid=75%.
      
 0.902
comA
Conserved protein; Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL).
  
  
 0.868
mtrA1
N5-methyl-tetrahydromethanopterin:coenzyme M methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
      
 0.835
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:PUR5_METJA AC:Q57656, p()=2.6E-81, pid=47%.
       0.764
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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