STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ribCRiboflavin synthase; Function Code:9.02 - Metabolism of Cofactors and Vitamins, Riboflavin metabolism; similar to, gp:GI:e218505:g1419079, p()=3.2E-76, pid=89%. (153 aa)    
Predicted Functional Partners:
ribH
Riboflavin synthase beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
  
  0.967
ribK
Conserved protein; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family.
    
  0.914
MTH_135
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64435 AC:B64435, p()=3E-50, pid=47%.
       0.780
MTH_133
Cobalt transport ATP-binding protein O; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).
       0.778
MTH_136
Function Code:11.04 - Cell envelope, dolichyl-phosphate mannose synthase; similar to, pir:LN:E64452 AC:E64452, p()=1.3E-30, pid=37%.
       0.754
ribB
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
 
   
 0.669
MTH_637
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:B64377 AC:B64377, p()=3.5E-15, pid=36%; Belongs to the UPF0235 family.
 
     0.638
MTH_138
GlcNAc-phosphatidylinositol related biosynthetic protein; Function Code:8.02 - Metabolism of Complex Lipids, Inositol phosphate metabolism; similar to, gp:GI:e304701:g1871598, p()=7.8E-12, pid=21%.
 
     0.634
MTH_137
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:C64497 AC:C64497, p()=0.18, pid=07%.
       0.626
MTH_132
Cobalt transport protein Q; Function Code:12.05 - Cell Processes, Transport of cations; similar to, gp:GI:e237184:g1419077, p()=2.3E-91, pid=67%.
       0.475
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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