STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_1377Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:G64486 AC:G64486, p()=7E-10, pid=29%; Belongs to the UPF0127 family. (123 aa)    
Predicted Functional Partners:
MTH_1702
Secretory protein kinase; Function Code:13.09 - Other, Conjugation; similar to, pir:LN:E64397 AC:E64397, p()=1.5E-89, pid=39%.
 
     0.741
MTH_1703
Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:C64397 AC:C64397, p()=0.018, pid=10%.
 
     0.692
MTH_980
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:C64397 AC:C64397, p()=0.000085, pid=10%.
 
     0.685
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
       0.646
mat
Conserved protein; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
       0.598
MTH_1373
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:H64441 AC:H64441, p()=9.6E-13, pid=25%.
 
     0.596
MTH_1840
Cell division inhibitor; Function Code:12.07 - Cell Processes, Cell division; similar to, sp:LN:Y547_METJA AC:Q57967, p()=9.1E-56, pid=46%.
 
     0.591
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
       0.584
polC
Conserved protein; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
 
     0.533
korA
2-oxoglutarate oxidoreductase, alpha subunit; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, pir:LN:E64334 AC:E64334, p()=3.6E-116, pid=57%.
       0.436
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.