STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_1456Chromosome partitioning protein Soj; Function Code:12.12 - Cell Processes, Broad regulatory functions; similar to, sp:LN:SOJ_BACSU AC:P37522, p()=3.8E-57, pid=48%. (218 aa)    
Predicted Functional Partners:
MTH_1282
Inosine-5'-monophosphate dehydrogenase related protein VI; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:Y188_METJA AC:Q57647, p()=1.7E-61, pid=41%.
  
 
 0.976
MTH_1457
Unknown; Function Code:14.00 - Unknown.
     
 0.944
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
  
 0.740
MTH_1840
Cell division inhibitor; Function Code:12.07 - Cell Processes, Cell division; similar to, sp:LN:Y547_METJA AC:Q57967, p()=9.1E-56, pid=46%.
 
  
 0.715
MTH_1515
GTP-binding protein; Function Code:13.07 - Other, Unclassified; similar to, pir:LN:C64466 AC:C64466, p()=7.8E-114, pid=52%.
  
  
 0.691
thrS
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.676
MTH_547
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1881240 LN:AB001488, p()=2E-28, pid=28%.
  
  
 0.667
MTH_1916
Biotin acetyl-CoA carboxylase ligase/biotin operon repressor; Function Code:9.06 - Metabolism of Cofactors and Vitamins, Biotin metabolism (B8); similar to, sp:LN:BIRA_BACSU AC:P42975, p()=4.5E-31, pid=29%; bifunctional.
     
 0.593
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.533
srp54
Signal recognition particle protein SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
  
 0.527
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.