Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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ubiXPhenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (191 aa)    
Predicted Functional Partners:
MTH_1394
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YPUE_METSM AC:P22349, p()=3E-135, pid=59%; Belongs to the UbiD family.
 
 0.998
MTH_148
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:A64444 AC:A64444, p()=3.4E-56, pid=32%.
  
    0.914
MTH_47
Conserved protein; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with dimethylallyl phosphate (DMAP) and isopentenyl thiolophosphate (ISP). Has low activity with 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro). Belongs to the isopentenyl phosphate kinase family.
    
  0.907
cbiT
precorrin-8W decarboxylase; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
       0.879
MTH_1425
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase fami [...]
       0.738
MTH_1421
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:H64463 AC:H64463, p()=1.7E-116, pid=54%; To M.jannaschii MJ1313.
       0.714
MTH_1629
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y240_METJA AC:Q57692, p()=1.9E-32, pid=40%.
       0.714
cofD
Conserved protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
       0.707
MTH_149
Molybdenum cofactor biosynthesis protein MoaE; Function Code:9.11 - Metabolism of Cofactors and Vitamins, Molybdopterin; similar to, gp:GI:g1825695, p()=2.5E-10, pid=28%.
     
 0.673
srp54
Signal recognition particle protein SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
       0.638
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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