STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
MTH_1497Cobyrinic acid a,c-diamide synthase related protein; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, sp:LN:Y138_METJA AC:Q57602, p()=7.1E-72, pid=36%. (490 aa)    
Predicted Functional Partners:
cbiJ
Cobalamin biosynthesis protein J; Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B.
 
  
 0.890
cbiC
Precorrin isomerase; Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family.
 
  
 0.881
MTH_1348
Precorrin-2 methyltransferase; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, pir:LN:C64396 AC:C64396, p()=4.8E-27, pid=32%; Belongs to the precorrin methyltransferase family.
 
  
 0.876
cbiH
Precorrin-3 methylase; Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity).
 
  
 0.849
MTH_602
Precorrin-3 methylase; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, pir:LN:A64497 AC:A64497, p()=3.3E-74, pid=58%.
 
  
 0.847
cbiD
Cobalamin biosynthesis protein D; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.835
gatA
Amidase; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln) (By similarity).
       0.781
cbiA
Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
 
  
 0.769
cobS
Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
  
 0.713
MTH_1408
Cobalamin biosynthesis protein G; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, sp:LN:CBIG_SALTY AC:Q05631, p()=1.2E-32, pid=29%.
 
  
 0.668
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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