STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_1502Succinate dehydrogenase, flavoprotein subunit; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:Y033_METJA AC:Q60356, p()=2.9E-139, pid=51%. (558 aa)    
Predicted Functional Partners:
MTH_1549
NADP-reducing hydrogenase, subunit C; Function Code:2.01 - Energy Metabolism, Oxidative phosphorylation; similar to, pir:LN:C57150 AC:C57150, p()=1.2E-133, pid=38%.
  
 
 0.996
MTH_1850
Fumarate reductase; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:Y092_METJA AC:Q57557, p()=6.9E-106, pid=43%.
 
 0.995
sucD
succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 0.995
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.994
iorA
Indolepyruvate oxidoreductase, alpha subunit; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
  
 
 0.969
MTH_1115
Fumarate hydratase, class I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:A64377 AC:A64377, p()=0.000000056, pid=28%.
 
 
 0.966
MTH_1735
Fumarate hydratase, class I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:E64461 AC:E64461, p()=2E-60, pid=45%.
  
 
 0.961
MTH_1910
Fumarate hydratase, class I related protein; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:A64377 AC:A64377, p()=1.2E-37, pid=38%.
  
 
 0.961
MTH_963
Fumarate hydratase, class I related protein; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:E64461 AC:E64461, p()=0.0000095, pid=16%.
  
 
 0.961
nadC
Quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
   
 0.949
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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