Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_159Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (226 aa)    
Predicted Functional Partners:
MTH_158
Ferritin like protein (RsgA); Function Code:12.05 - Cell Processes, Transport of cations; similar to, sp:LN:FTN2_HAEIN AC:P43708, p()=5.8E-22, pid=31%.
  
  
 0.972
sod
Superoxide dismutase (Fe/Mn); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.945
hcp
6Fe-6S prismane-containing protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
  
 
 0.940
MTH_708
Thioredoxin reductase; Function Code:4.02 - Nucleotide Metabolism, Pyrimidine metabolism; similar to, gp_new:GI:e313024:g1945648 LN:BSZ94043, p()=3.8E-57, pid=42%.
  
 
 0.934
mre11
Rad32 related protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 
 0.930
MTH_157
Flavoprotein A homolog (III); Function Code:13.07 - Other, Unclassified; similar to, pir:LN:S66533 AC:S66533, p()=4.1E-60, pid=68%.
  
  
 0.923
MTH_1095
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1653851 LN:D90917, p()=0.000000003, pid=35%.
  
 0.913
MTH_1745
Protein disulphide isomerase; Function Code:10.08 - Metabolism of Macromolecules, Protein translation and modification; similar to, gp:GI:g699219 LN:MLU15182, p()=0.000000021, pid=22%.
  
 0.913
MTH_807
Thioredoxin; Acts to maintain redox homeostasis; functions as a protein disulfide reductase; Belongs to the glutaredoxin family.
  
 0.913
MTH_895
Conserved protein; Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.
  
 0.913
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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