STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dutDeoxycytidine-triphosphate deaminase related protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (150 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
  
 
 0.937
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.934
MTH_1100
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:KTHY_METJA AC:Q57741, p()=0.0000032, pid=19%.
  
 
 0.928
tmk
Thymidylate kinase; Function Code:4.04 - Nucleotide Metabolism, Salvage and interconversion; similar to, sp:LN:KTHY_METJA AC:Q57741, p()=5.2E-21, pid=32%.
  
 
 0.928
surE
Survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.916
MTH_1539
Anaerobic ribonucleoside-triphosphate reductase; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, pir:LN:H64403 AC:H64403, p()=2.5E-200, pid=51%.
    
 0.916
dcd
Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
     
  0.900
MTH_1792
dTDP-4-dehydrorhamnose reductase; Function Code:1.05 - Carbohydrate Metabolism, Fructose and mannose metabolism; similar to, gp:GI:g1881547 LN:SPU09239, p()=8.7E-51, pid=39%.
   
    0.573
MTH_1606
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:YDCE_ECOLI AC:P31992, p()=0.0069, pid=22%.
       0.562
MTH_1016
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g385923 LN:S61233, p()=1.1E-50, pid=43%.
 
   
 0.499
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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