STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_1628Unknown; Function Code:14.00 - Unknown; similar to, pir:LN:S63993 AC:S63993:S63992, p()=0.08, pid=26%. (127 aa)    
Predicted Functional Partners:
MTH_1629
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y240_METJA AC:Q57692, p()=1.9E-32, pid=40%.
       0.547
tbp
TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).
       0.490
MTH_1626
Phosphoserine phosphatase; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, pir:LN:A64499 AC:A64499, p()=3.3E-51, pid=21%.
       0.489
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.479
MTH_1625
Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:KRUP_EUSPL AC:Q01871, p()=0.037, pid=16%.
       0.479
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.