STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
MTH_1636S-adenosylhomocysteine hydrolase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. (417 aa)    
Predicted Functional Partners:
metE
Cobalamin-independent methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate (By similarity).
  
 
 0.983
MTH_495
Modification methyltransferase, cytosine-specific; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, sp:LN:MTD1_DESDN AC:P05302, p()=8.6E-37, pid=30%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.919
MTH_854
Ferredoxin; Function Code:2.08 - Energy Metabolism, Electron transport; similar to, sp:LN:FER2_METJA AC:Q57563, p()=6.7E-21, pid=29%.
     
  0.900
MTH_855
Inosine-5'-monophosphate dehydrogenase related protein VIII; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:Y100_METJA AC:Q57564, p()=2.2E-157, pid=64%.
     
  0.900
MTH_1232
Homoserine dehydrogenase; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, sp:LN:DHOM_SYNY3 AC:P52986, p()=8.8E-90, pid=46%.
  
 
 0.846
MTH_417
Homoserine dehydrogenase homolog; Function Code:5.02 - L-Amino Acid Metabolism, Glycine--serine and threonine metabolism; similar to, pir:LN:A64500 AC:A64500, p()=2.1E-79, pid=49%.
  
 
 0.846
MTH_1635
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, pir:LN:E64362 AC:E64362, p()=4.8E-27, pid=28%.
       0.798
rpl13/rps9
Ribosomal protein S16 (E.coli); L13 protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity).
  
  
 0.755
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) instead of H4MPT as the pteridine substrate. Also probably exhibits a pteridine- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.735
fusA
Translation elongation factor, EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase [...]
  
 
 0.689
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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