STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemDUroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (253 aa)    
Predicted Functional Partners:
MTH_167
S-adenosyl-L-methionine uroporphyrinogen methyltransferase; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, pir:LN:A42471 AC:A42471, p()=5.9E-84, pid=64%; Belongs to the precorrin methyltransferase family.
 
 0.999
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
 0.999
hemB
Porphobilinogen synthase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
 
 
 0.990
MTH_602
Precorrin-3 methylase; Function Code:9.10 - Metabolism of Cofactors and Vitamins, Porphyrin and chlorophyll metabolism; similar to, pir:LN:A64497 AC:A64497, p()=3.3E-74, pid=58%.
   
 0.946
srp19
Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
       0.919
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.898
MTH_1013
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:e288126:g1752671, p()=1E-13, pid=25%.
 
 
 0.892
MTH_164
Single-stranded DNA exonuclease RecJ related protein; Function Code:10.11 - Metabolism of Macromolecules, DNA degradation--restriction/modification; similar to, pir:LN:A64422 AC:A64422, p()=4.9E-57, pid=32%.
       0.868
cbiX
Conserved protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel- containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation (Potential). Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin (Potential).
  
  
 0.835
hemL
Glutamate-1-semialdehyde aminotransferase; Function Code:9.01 - Metabolism of Cofactors and Vitamins, Thiamine metabolism; similar to, sp:LN:GSA_METJA AC:Q58020, p()=1.9E-135, pid=58%; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
  
 0.833
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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