STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhLactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. (325 aa)    
Predicted Functional Partners:
MTH_1726
Citrate synthase I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:CYSZ_CUCMA AC:P49299, p()=1.6E-15, pid=28%.
  
 0.994
MTH_962
Citrate synthase I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:CYSZ_CUCMA AC:P49299, p()=6.4E-16, pid=30%.
  
 0.994
sucC
succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.975
MTH_1735
Fumarate hydratase, class I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:E64461 AC:E64461, p()=2E-60, pid=45%.
  
 
 0.963
MTH_1115
Fumarate hydratase, class I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:A64377 AC:A64377, p()=0.000000056, pid=28%.
  
 
 0.962
MTH_1910
Fumarate hydratase, class I related protein; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:A64377 AC:A64377, p()=1.2E-37, pid=38%.
  
 
 0.962
MTH_963
Fumarate hydratase, class I related protein; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, pir:LN:E64461 AC:E64461, p()=0.0000095, pid=16%.
  
 
 0.962
gap
Glyceraldehyde 3-phosphate dehydrogenase; Function Code:1.01 - Carbohydrate Metabolism, Glycolysis--Gluconeogenesis; similar to, pir:LN:S02804 AC:S02804, p()=7.6E-139, pid=76%.
 
 
 0.959
pycB
Oxaloacetate decarboxylase, alpha subunit; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
    
 0.951
MTH_1894
Aspartate aminotransferase homolog; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, sp:LN:AAT_METJA AC:Q60317, p()=6.1E-82, pid=46%.
  
 0.943
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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