STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_192Tungsten formylmethanofuran dehydrogenase, subunit C homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64446 AC:B64446, p()=0.0000024, pid=20%. (229 aa)    
Predicted Functional Partners:
MTH_194
Glutamate synthase (NADPH), alpha subunit; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, pir:LN:F64468 AC:F64468, p()=2.2E-90, pid=42%; Belongs to the glutamate synthase family.
    0.993
MTH_105
Glutamate synthase (NADPH), alpha subunit; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, pir:LN:F64468 AC:F64468, p()=7E-77, pid=33%; Belongs to the glutamate synthase family.
  
 0.982
MTH_193
Coenzyme F420-reducing hydrogenase, beta subunit homolog; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:FRHB_METJA AC:Q60341, p()=3.3E-35, pid=31%.
  
    0.974
MTH_191
Glutamine PRPP amidotransferase; Function Code:4.01 - Nucleotide Metabolism, Purine metabolism; similar to, sp:LN:PUR1_SYNP7 AC:Q55038, p()=1.7E-21, pid=22%.
 
  
 0.963
MTH_1666
Glutamate synthase (NADPH), alpha subunit related protein; Function Code:5.01 - L-Amino Acid Metabolism, Alanine--aspartate and glutamate metabolism; similar to, pir:LN:F64468 AC:F64468, p()=2E-51, pid=25%; Belongs to the glutamate synthase family.
    0.914
pdxT
Conserved protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
       0.790
MTH_189
Unknown; Function Code:14.00 - Unknown; similar to, gp:GI:g1498542 LN:HSU64486, p()=0.08, pid=18%.
       0.757
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
   
    0.611
mdh
Lactate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
       0.524
MTH_187
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, gp:GI:g1651830 LN:D90900, p()=1.6E-12, pid=82%.
       0.502
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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