STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_205Hydrogenase expression/formation protein HypE; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:D64384 AC:D64384, p()=3.2E-92, pid=45%. (376 aa)    
Predicted Functional Partners:
MTH_1072
Hydrogenase expression/formation protein HypD; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:A64424 AC:A64424, p()=1.9E-85, pid=47%.
 
 0.999
MTH_1287
Transcriptional regulator HypF homolog; Function Code:10.02 - Metabolism of Macromolecules, Transcription--mRNA synthesis and modification (includes regulators); similar to, pir:LN:A64389 AC:A64389, p()=1.3E-161, pid=43%; Belongs to the carbamoyltransferase HypF family.
 
 
 0.998
MTH_1649
Hydrogenase expression/formation protein HypC; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:Y200_METJA AC:Q57653, p()=2.1E-17, pid=49%.
 
 
 0.998
frhA
Coenzyme F420-reducing hydrogenase, alpha subunit; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
   
 0.823
hypA
Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.797
MTH_204
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YGFA_ECOLI AC:P09160, p()=0.00076, pid=12%.
       0.755
MTH_782
Hydrogenase expression/formation protein HypB; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64355 AC:B64355, p()=6.3E-64, pid=58%.
 
  
 0.732
MTH_206
Unknown; Function Code:14.00 - Unknown; similar to, gp_new:GI:e315172:g2078069, p()=0.75, pid=21%.
       0.718
MTH_398
Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:C64364 AC:C64364, p()=8.5E-92, pid=46%.
   
 
 0.617
MTH_1238
Formate hydrogenlyase, subunit 5; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, pir:LN:B64428 AC:B64428, p()=2E-99, pid=47%.
   
 
 0.616
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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