STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_216acetyl-CoA synthetase; Function Code:1.08 - Carbohydrate Metabolism, Pyruvate and acetyl-CoA metabolism; similar to, pir:LN:B47682 AC:B47682, p()=7.6E-11, pid=47%. (43 aa)    
Predicted Functional Partners:
MTH_215
FUN34 related protein; Function Code:13.0=7 - Other, Unclassified; similar to, sp:LN:YAAH_ECOLI AC:P28695, p()=1.1E-34, pid=38%.
  
  
 0.816
MTH_217
acetyl-CoA synthetase; Function Code:1.08 - Carbohydrate Metabolism, Pyruvate and acetyl-CoA metabolism; similar to, gp:GI:g1001254, p()=1E-159, pid=52%.
     
 0.784
mer
Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
     
 0.756
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Cannot use tetrahydrofolate (THF or H4PteGlu) instead of H4MPT as the pteridine substrate. Also probably exhibits a pteridine- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 
 0.754
ehaS
Formylmethanofuran:tetrahydromethanopterin formyltransferase II; Function Code:2.02 - Energy Metabolism, Methane metabolism; similar to, sp:LN:FTR_METTH AC:P21348, p()=1.6E-44, pid=36%; Belongs to the FTR family.
      
 0.748
fbp
Conserved protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.738
MTH_657
long-chain-fatty-acid-CoA ligase; Function Code:3.01 - Lipid Metabolism, Fatty acid biosynthesis; similar to, gp:GI:e276127:g1627854, p()=3.2E-101, pid=37%.
  
 
 0.639
MTH_1726
Citrate synthase I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:CYSZ_CUCMA AC:P49299, p()=1.6E-15, pid=28%.
  
 
 0.632
MTH_962
Citrate synthase I; Function Code:1.02 - Carbohydrate Metabolism, Citrate cycle (TCA cycle); similar to, sp:LN:CYSZ_CUCMA AC:P49299, p()=6.4E-16, pid=30%.
  
 
 0.632
MTH_1523
Glucose-1-phosphate adenylyltransferase related protein; Function Code:4.03 - Nucleotide Metabolism, Nucleotide sugars metabolism; similar to, sp:LN:MPG1_YEAST AC:P41940, p()=2E-21, pid=20%.
  
  
 0.588
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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