Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MTH_221Unknown; Function Code:14.00 - Unknown; similar to, sp:LN:FER2_DESDN AC:P00211, p()=0.48, pid=05%. (270 aa)    
Predicted Functional Partners:
MTH_1365
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:FER5_METJA AC:Q57699, p()=0.00000083, pid=24%.
   
 0.871
MTH_222
Unknown; Function Code:14.00 - Unknown.
       0.531
queC
Conserved protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
     
 0.515
tgtA
tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
  
  
 0.502
queD
Conserved protein; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
     
 0.469
nnr
Conserved protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity). In the N-terminal section; belongs to the NnrE/AIBP family.
     
 0.448
MTH_220
Flavoprotein A homolog (II); Function Code:13.07 - Other, Unclassified; similar to, pir:LN:D64393 AC:D64393, p()=8.2E-142, pid=62%.
       0.447
cpgS
Unknown; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP. Not able to catalyze cDPG hydrolysis. May be involved in osmotic balance.
       0.433
MTH_639
Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:Y206_METJA AC:Q57659, p()=3.3E-26, pid=43%.
   
    0.414
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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