STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MTH_247Conserved protein; Function Code:14.01 - Unknown, Conserved protein; similar to, sp:LN:YD11_METJA AC:Q58707, p()=3.3E-26, pid=32%. (233 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family.
       0.919
MTH_246
Twitching mobility (PilT) related protein; Function Code:11.03 - Cell envelope, Surface proteins, glycoproteins, and structures; similar to, pir:LN:D64491 AC:D64491, p()=4.9E-133, pid=44%.
       0.919
hisS
histidyl-tRNA synthetase; Function Code:10.07 - Metabolism of Macromolecules, Aminoacyl tRNA synthetases and tRNA modification; similar to, sp:LN:SYH_METJA AC:Q58406, p()=8.8E-90, pid=40%; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.909
MTH_875
3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein; Function Code:13.07 - Other, Unclassified; similar to, gp:GI:g1001423, p()=5.8E-38, pid=31%.
  
  
 0.839
MTH_212
Exodeoxyribonuclease; Involved in DNA uracil repair. Recognizes DNA uracil residues within double-stranded DNA and initiates DNA-U repair by endonucleotic incision on the 5'-side of the 2'-d-uridine residue, irrespective of the nature of the opposing nucleotide. In addition, acts as an apurinic/apyrimidinic (AP) endonuclease hydrolyzing the DNA phosphodiester backbone immediately at the 5'-side of AP sites, and as a 3'-5' exonuclease. Strongly binds to double-stranded DNA.
     
 0.815
MTH_243
Conserved protein; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.
       0.780
endA
tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
       0.750
MTH_404
Ribokinase; Function Code:1.03 - Carbohydrate Metabolism, Pentose phosphate cycle; similar to, sp:LN:RBSK_HAEIN AC:P44331, p()=1.1E-20, pid=27%; Belongs to the carbohydrate kinase PfkB family.
 
  
 0.623
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
  
 0.584
MTH_1544
Ribokinase; Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates, using ATP, ITP or GTP as phosphate donor.
  
  
 0.573
Your Current Organism:
Methanothermobacter thermautotrophicus
NCBI taxonomy Id: 187420
Other names: M. thermautotrophicus str. Delta H, Methanobacterium thermoautotrophicum str. Delta H, Methanobacterium thermoautotrophicum str. deltaH, Methanothermobacter thermautotrophicus str. Delta H, Methanothermobacter thermautotrophicus str. deltaH
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